Oral THC and CBD Together: Why Formulation Matters

Research summary

Research comparing oral THC administered in different cannabinoid formulations highlights the need to evaluate pharmacokinetics and pharmacodynamics together. Forensic interpretation should specify the administered dose, CBD coadministration, route, biological matrix, and time of measurement. Findings from controlled oral dosing cannot automatically be transferred to inhaled cannabis, different extracts, or unknown consumer-product compositions.

Forensic interpretation

This research describes specific experimental conditions. It does not establish an individual driver’s impairment or the cause of an observed clinical finding without case-specific information. Analytical methodology, timing, dose, route of administration, and plausible alternative explanations should be assessed before making a forensic inference.

Primary research

Read the peer-reviewed research (PMC PMC9926328).