The THC Heart-Rate Dose Meta-Regression Did Not Provide an Individual Dose Calculator
The cardiovascular review found a relationship between THC dose and human heart-rate effect across studies. That meta-regression did not establish a precise pulse change for a particular person.
The analysis concerned study-level effects
The review reports dose-dependent tachycardia in its human analysis and discusses oral trials using several THC doses. Meta-regression relates dose conditions to estimated effects across the included comparisons. It does not automatically reconstruct the exposure-response curve of an individual participant.
Route and timing also changed the exposure
The authors identify heterogeneity in administration route, dose and assessment time. A labeled dose does not ensure a matching peak concentration across those conditions. Combining the study results therefore cannot supply a single conversion from milligrams of THC to beats per minute for clinical or forensic use.
Pulse is not an impairment measurement
The association does not establish that a larger pulse increase always means greater cognitive impairment, nor that an unchanged pulse excludes a drug effect. Those conclusions require their own functional evidence. The useful contribution is a group-level physiological dose signal within a limited historical evidence base. An accurate account preserves the analysis level and protocol variation rather than turning the result into a personal dosing or last-use estimate.
Related analysis: the study’s broader findings and limitations.
