Tag Archives: cannabis pharmacokinetics

Concentration Is Not Impairment: THC Blood Levels in California Driving Cases

California has no per se THC limit, and the pharmacology explains why. Blood THC falls fastest when effect is still rising, and frequent users carry measurable levels long after any effect.

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Recent Blog Articles

Why a SCRAM Alert Cannot Pinpoint the Time of a First Drink

The timestamp on a SCRAM report identifies a point in the monitoring record. Estimating the time of a first drink requires a separate analysis and independent information about the timeline.

Read Article: Why a SCRAM Alert Cannot Pinpoint the Time of a First Drink

Hundreds of Plasma Specimens Still Came From Six THC Participants

The study’s 264 plasma specimens did not represent 264 independent cannabis users. Repeated sampling increased information about each participant’s profile while leaving the human sample small. The denominator depended on the question The intensive inpatient study enrolled six established cannabis users and repeatedly measured cannabinoids during and after oral dronabinol…

Read Article: Hundreds of Plasma Specimens Still Came From Six THC Participants

Metabolite Ratios Rose During Repeated Oral THC While Parent THC Did Not Accumulate Similarly

During repeated dosing, 11-hydroxy-THC and THC-COOH increased over time without the same accumulation pattern for parent THC. A stable parent profile did not mean all measured cannabinoid exposure remained stable. The analytes followed different courses The six-person plasma study compared repeated oral dosing with measurements associated with cannabis use before…

Read Article: Metabolite Ratios Rose During Repeated Oral THC While Parent THC Did Not Accumulate Similarly