The Canine THC–CBD Combination Dose Was Defined by THC Rather Than Total Cannabinoids
A combination-oil dose in the canine study referred to its THC amount, with CBD added alongside it. Reading the number as the combined mass of both cannabinoids would understate the administered mixture.
The oil concentrations defined the arithmetic
The combination product contained 27 mg/mL THC and 25 mg/mL CBD. The investigators calculated the administered combination dose using THC concentration. Consequently, each nominal 1 mg/kg of combination treatment included 1 mg/kg THC and approximately 0.93 mg/kg CBD.
The schedule also accumulated exposure
The dogs received incremental administrations at two-hour intervals, producing cumulative nominal levels of 1, 2, 4, 8 and 16 mg/kg. Those later levels incorporated earlier administrations. The combination’s labeled level therefore should not be mistaken for a fresh independent single dose or for the sum of THC plus CBD.
Comparison requires both components
This distinction matters when comparing the combination with THC alone or CBD alone. A statement that all treatments had the same cannabinoid dose can hide which active component was matched. Plasma concentrations supplied additional exposure information, but did not make the products chemically identical. The study does not provide a dosing recommendation for pets or a human conversion formula. Its practical lesson for research interpretation is to identify whether a reported combination dose is based on one ingredient, total active ingredients or volume before connecting that number to physiological findings.
Related analysis: the canine study’s separate physiological outcomes.
Research cited
Rutjanavate, Dong and Sawangkoon. Cumulative Effects of Cannabis Oils on Body Temperature, Electrocardiography, Heart Rate Variability, Blood Pressure, and Respiratory Function in Telemetered Dogs. DOI: 10.4103/IJVSM.IJVSM_3_25.
