Monthly Archives: September 2015
Testing and Toxicology of Designer Drugs
This article explains Testing and Toxicology of Designer Drugs and the scientific, legal or practical evidence readers should understand.
This article explains Testing and Toxicology of Designer Drugs and the scientific, legal or practical evidence readers should understand.
An increase in tissue endocannabinoid content does not directly establish release onto a particular neuronal pathway. A review distinguishes a plausible alcohol-reward circuit from the measurements needed to test it locally. Several evidence streams supported a model Pava and Woodward combine findings involving dopamine responses, CB1 interventions and endocannabinoid measurements…
Read Article: Bulk Endocannabinoid Content Does Not Directly Measure Release at a Specific Synapse
Calling alcohol a central nervous system depressant does not rule out calcium-dependent endocannabinoid release in a neuronal preparation. A review describes intracellular calcium mechanisms that help reconcile those observations. A global drug label does not specify every cellular event Pava and Woodward discuss brief alcohol exposure increasing intracellular calcium in…
Read Article: Alcohol-Related Endocannabinoid Release Can Depend on Intracellular Calcium
A normal circulating stress-hormone measurement does not necessarily establish normal concentrations in brain tissue. A review raises this compartment distinction when discussing possible interactions with endocannabinoid signaling after alcohol exposure. The sampled compartment changed the observation Pava and Woodward describe corticosterone remaining elevated in brain tissue after chronic alcohol treatment…