A Daily THC Regimen Included Exceptions on Challenge-Test Days
A regimen described as daily THC treatment did not mean an identical maintenance dose on every calendar day. A mouse study omitted that dose on days when challenge drugs were administered during testing.
The methods defined the actual schedule
Singh and colleagues used a repeated THC regimen with a six-hour pre-session interval. Fifty-six days elapsed between the first and last treatment days, but the scheduled maintenance injection was replaced with vehicle on cumulative-dose challenge days.
The label alone would lose exposure detail
Counting elapsed days as the number of identical maintenance injections would misdescribe the protocol. Challenge testing also involved drug administration, so an omitted maintenance injection should not automatically be called a drug-free day. The exposure history includes both the maintenance schedule and the test-session doses.
Reconstruct the protocol before interpreting adaptation
Frequency, timing and interruptions can matter when comparing tolerance studies. This experiment does not independently isolate the effect of its omitted doses, because the omissions were part of the testing design rather than a randomized intervention. It nevertheless provides a clear reporting lesson: daily, chronic and continuous are not substitutes for the actual dosing record. The same care prevents an experimental schedule from being converted into an unsupported claim about abstinence or recovery in cannabis users.
Related analysis: Outcome-specific cannabinoid cross-tolerance.
Research cited
Singh H, Schulze DR, McMahon LR. Tolerance and cross-tolerance to cannabinoids in mice: schedule-controlled responding and hypothermia (2011).
