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A 1985 rat experiment reported withdrawal-like behavior and regional histamine decreases after clomipramine challenge in THC-tolerant animals. The design was a pharmacological challenge, not simply observation after THC cessation. Tolerance was established before the challenge Repeated intravenous THC produced tolerance to cooling and to the acute regional histamine reductions over…
A 1986 mouse study reported prolonged susceptibility to electrically induced convulsions after THC, while repeated treatment produced tolerance to motor toxicity but not that excitability endpoint. Adaptation differed between visible movement effects and a later electrical challenge. The exposure was a high-dose injected protocol The experiment examined a wide high-dose…
A 1987 rat experiment found environmental familiarity affected THC behavior in drug-naive animals but not in animals previously exposed to THC. The finding was an interaction between two histories, not proof that context never matters. Drug and chamber exposure were separated Four groups received prior drug exposure, prior chamber exposure,…
Read Article: Prior THC Exposure Changed Whether Environmental Familiarity Mattered in a Rat Study