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The study’s 264 plasma specimens did not represent 264 independent cannabis users. Repeated sampling increased information about each participant’s profile while leaving the human sample small. The denominator depended on the question The intensive inpatient study enrolled six established cannabis users and repeatedly measured cannabinoids during and after oral dronabinol…
Read Article: Hundreds of Plasma Specimens Still Came From Six THC Participants
During repeated dosing, 11-hydroxy-THC and THC-COOH increased over time without the same accumulation pattern for parent THC. A stable parent profile did not mean all measured cannabinoid exposure remained stable. The analytes followed different courses The six-person plasma study compared repeated oral dosing with measurements associated with cannabis use before…
The intensive oral-THC regimen repeatedly used 20 mg capsules while shortening the intervals between administrations. A higher daily total did not mean every individual capsule dose became larger. The schedule defined exposure Six daily cannabis users received dronabinol at increasing frequency, with intervals described as every four to eight hours…
Read Article: Repeated Oral THC Increased Daily Dose by Changing Administration Frequency